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Japan: protein condensates and cell adhesion

This dossier follows research on protein condensates in cell skeleton organisation and adhesion between cells. Experimental findings are distinguished from medical applications.

Last updated : 1 key moments
Tokushima University in 2007.
Tokushima University, 23 September 2007. Archive campus photograph; it does not depict the experiments. — Sorrysorry / Wikimedia Commons — domaine public ; 23 septembre 2007, sans modification.

Where things stand

On 30 October 2026, Tokushima University presents a study published on 29 October at 9 p.m. in Japan on JRAB/MICAL-L2 and Rab13. The results concern laboratory experiments.

Reported information

Tokushima describes how protein droplets modulate the cell skeleton

A team at Tokushima University in Japan reports that the composition of protein droplets can change their stiffness and their effects on actin fibres, which support cells. The study appeared in the Journal of Cell Science on 29 October 2026, according to the university's 30 October statement.

Tokushima University in 2007.
Tokushima University, 23 September 2007. Archive campus photograph; it does not depict the experiments. — Sorrysorry / Wikimedia Commons — domaine public ; 23 septembre 2007, sans modification.

In experiments with purified proteins, adding Rab13 to droplets formed by JRAB/MICAL-L2 increases their stiffness about 1.5-fold and reduces the area of actin bundle formation to about one tenth.

The researchers also observed disrupted adhesion structures in epithelial cells lacking JRAB/MICAL-L2. These observations suggest a link between droplet composition, physical properties and cellular organisation.

This is basic research: the findings do not demonstrate a treatment's effectiveness. Independent experimental corroboration is not established in the documents consulted.

Sources 3